. "Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17"^^ . "Edited: Garapati, P V, 2010-07-07"^^ . "Authored: Garapati, P V, 2010-07-07"^^ . "TYK2 functions as part of a receptor complex to trigger intracellular signaling in response to IFNA/B. TYK2 bound to IFNAR1 subunit is activated in response to IFNA/B treatment and this in turn phosphorylates two tyrosine residues Y466 and Y481 in the juxta-membrane region of IFNAR1."^^ . . . . . . . "Phosphorylation of INFAR1 by TYK2"^^ . "2.7.10"^^ . . . . . . .