. "Reviewed: Antonellis, A, 2008-12-02 16:58:45"^^ . "Authored: D'Eustachio, P, 2008-11-29 15:41:00"^^ . "Edited: D'Eustachio, P, 2008-11-29 15:41:00"^^ . "YARS (cytosolic tyrosyl tRNA synthetase) catalyzes the reaction of tyrosine, tRNA(Tyr), and ATP to form Tyr tRNA(Tyr), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Yang et al. 2003). Mutations in the YARS gene are associated with dominant-intermediate Charcot-Marie-Tooth disease \u00E2?? a form of peripheral neuropathy characterized by axon and Schwann cell dysfunction (Jordanova et al. 2006)."^^ . . . . . . . "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate"^^ . "6.1.1.1"^^ . . . . . . .