. "KARS (cytosolic lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997)."^^ . "Reviewed: Antonellis, A, 2008-12-02 16:58:45"^^ . "Authored: D'Eustachio, P, 2008-11-29 15:41:00"^^ . "Edited: D'Eustachio, P, 2008-11-29 15:41:00"^^ . . . . . . "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate"^^ . "6.1.1.6"^^ . . . . . . .