. "Reviewed: Antonellis, A, 2008-12-02 16:58:45"^^ . "Authored: D'Eustachio, P, 2008-11-29 15:41:00"^^ . "Edited: D'Eustachio, P, 2008-11-29 15:41:00"^^ . "IARS (cytosolic aspartyl tRNA synthetase) catalyzes the reaction of isoleucine, tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is found in the cell as a component of the mutienzyme aminoacyl-tRNA synthetase complex (Shiba et al. 1994)."^^ . . . . . . "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate"^^ . "6.1.1.5"^^ . . . . . . .