. "Reviewed: Gillespie, ME, 2010-11-30"^^ . "Authored: Shamovsky, V, 2010-06-01"^^ . "Edited: Shamovsky, V, 2010-11-16"^^ . "TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a complex that also contains TAK1 and TAB1, binds polyubiquitinated TRAF6. The TAB2 and TAB3 regulatory subunits of the TAK1 complex contain C-terminal nuclear zinc finger motifs that interact with K63-pUb chains (Kanayama et al. 2004). TAK1 can be activated by unattached K63-polyubiquitinated chains when TRAF6 has no detectable polyubiquitination (Xia et al. 2009) and thus the synthesis of these chains by TRAF6 may be the signal transduction mechanism."^^ . . . . . . . . "Activated TRAF6:p-IRAK2 interacts with TAK1 complex"^^ . . . . . . .