<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Akkerman, JW, 2009-06-03"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Heemskerk, JW, 2010-09-01"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Jupe, S, 2010-09-01"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#comment> "EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/9789079> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/16076873> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_392834> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_23933_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Activation of EPACs by cAMP"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule5> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein4418> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#participantStoichiometry> <http://www.reactome.org/biopax/48887Stoichiometry8514> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2450> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex3051> .