. "Reviewed: Trowsdale, J, 2007-08-06 19:33:04"^^ . "Authored: de Bono, B, 2007-07-08 12:58:15"^^ . "Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be expressed on telencepahlic neurons.

VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4).

To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change.

Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion."^^ . . . . . . "ICAMs 1-4 bind to Integrin LFA-1"^^ . . . .