<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Elliott, T, 2011-02-10"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Garapati, P V, 2010-10-29"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Garapati, P V, 2010-10-29"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#comment> "Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/16595681> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/19352404> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/18662542> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_75782_1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_983153> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#displayName> "E1 mediated ubiquitin activation"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#eCNumber> "6.3.2.19"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule17> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein19> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein8447> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule17> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex2895> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule55> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2356> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule6> .