<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Garapati, P V, 2008-12-16 11:12:19"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Garapati, P V, 2008-12-16 11:12:19"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#comment> "The interaction of CD28 with its ligands, B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells enhances a number of TCR-mediated responses like production of interleukins. CD28 mediated costimulation is dependent upon phosphorylation of tyrosine residue 191 of the CD28 cytoplasmic tail, present in a 'YMNM' motif. p56Lck and p59Fyn phosphorylate CD28 and the phosphorylated residue allows the recruitment of PI3K, growth factor receptor-bound protein 2 (GRB2) and Grb2-related adaptor downstream of SHC (GADS) via their src-homology region 2 (SH2) domains."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/8946678> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/9973466> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_388831> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_19264_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Phosphorylation of CD28"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#eCNumber> "2.7.10"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein8227> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex2802> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#participantStoichiometry> <http://www.reactome.org/biopax/48887Stoichiometry7940> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#participantStoichiometry> <http://www.reactome.org/biopax/48887Stoichiometry7941> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#participantStoichiometry> <http://www.reactome.org/biopax/48887Stoichiometry7946> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2306> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex2803> .