<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Trowsdale, J, 2008-02-26 12:02:59"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#comment> "On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_12585_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_202407> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#displayName> "PLC-gamma1 hydrolyses PIP2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#eCNumber> "3.1.4.11"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule761> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule4> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule797> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2277> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule743> .