. "Edited: Rothfels, K, 2012-05-16"^^ . "Reviewed: Ezzat, S, 2012-05-15"^^ . "Authored: Rothfels, K, 2012-02-09"^^ . "Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established."^^ . . . . . . . . . . . . "Activated FGFR mutants bind PLC-gamma"^^ . . . . .