. "Edited: Rothfels, K, 2012-05-16"^^ . "Reviewed: Ezzat, S, 2012-05-15"^^ . "Expression of the FGFR4 Y367C mutant in MDA-MB453 breast cancer cell line results in constitutive tyrosine phosphorylation of the receptor and serum-independent activation of downstream signaling as monitored by Erk phosphorylation. Ectopic expression of FGFR4 Y367C in HEK cells also leads to Erk activation and enhanced cellular proliferation. Akt and phospho-AKT levels were not affected by overexpression of the FGFR4 Y367C mutant, however (Roidl, 2010)"^^ . "Authored: Rothfels, K, 2012-02-09"^^ . . . . . . "Autocatalytic phosphorylation of FGFR4 Y367C mutant"^^ . "2.7.10"^^ . . . . . . .