<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Mohammadi, M, 2007-02-06 21:44:35"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: de Bono, B, 2007-01-10 10:27:18"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Jupe, S, 2010-02-03"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#comment> "Recruitment of PLC-gamma by FGF receptors has been best studied in FGFR1c signaling, where it has been shown that autophosphorylation of Tyr766 in the C-terminal tail of FGFR1c creates a specific binding site for the SH2 domain of PLC-gamma. A mutant FGFR1c in which Y766 is replaced by phenylalanine is unable to activate PI hydrolysis and Ca2+ release in response to FGF stimulation. Membrane recruitment of PLC-gamma is also aided by binding of the Pleckstrin homology (PH) domain of this enzyme to PtIns(3,4,5) P3 molecules that are generated in response to PI-3 kinase stimulation. By sequence comparison, Y766 is conserved in all FGFR isoforms, and PLC-gamma signaling is observed, to a greater or lesser extent, downstream of all FGFR receptors upon stimulation with FGFs."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/1656221> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10652257> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/16844695> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/9430633> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_190896> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_21398_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Activated FGFR binds PLC-gamma"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule760> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein5162> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887PhysicalEntity383> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1776> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex2201> .