<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Timmers, H. T. M., 2003-09-11 07:42:30"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#comment> "Formation of the third phosphodiester bond creates a 4-nt product. This commits the initiation complex to promoter escape. The short 4-nt transcript is still loosely associated with the RNA polymerase II initiation complex and can dissociate to yield abortive products, which are not further extended. Inhibition of ATP-hydrolysis by TFIIH does not lead to collapse of the open region any longer. The transcription complex has lost the sensitivity to single-stranded oligo-nucleotide inhibition. However, ATP-hydrolysis and TFIIH are required for efficient promoter escape. The open region (\u00C3\u00A2\u00E2?\u00AC\u00C5?transcription bubble\u00C3\u00A2\u00E2?\u00AC\u00C2?) expands concomitant with the site of RNA-extension. In this case this region spans positions -9 to +4."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Joshi-Tope, G, 0000-00-00 00:00:00"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/11784853> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_1817_3> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/9405375> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_75869> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#eCNumber> "2.7.7.6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule40> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex246> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule45> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex247> .
<http://www.reactome.org/biopax/48887BiochemicalReaction175> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Protein1015> .