<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#comment> "IGFBP 5 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 5. IGFBP 5 also binds ALS via the central portion of IGFBP 5. About 55% of IGF:IGFBP 5 complexes contain ALS. IGFBP 5 is enriched in bone matrix and acts to stimulate IGF function. IGFBP 5 is cleaved by Pregnancy associated Plasma Protein A2 (PAPP A2), ADAM 9, complement C1s from smooth muscle, and thrombin. Only the cleavage site for PAPP A2 is known. About 55% of IGF:IGFBP 5 complexes contain ALS; 45% contain only IGF and IGFBP 5."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/12379487> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/17047378> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/12466191> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/7689487> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/7683646> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/8781553> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/7519608> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/9497324> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/15126567> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/11788658> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10810289> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_381545> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10614670> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/11316783> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/9786878> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_15355_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Formation of the IGF:IGFBP-5:ALS Complex"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein6829> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein6825> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein6832> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1732> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex2147> .