<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: May, B, 2009-06-02 00:51:49"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: May, B, 2009-06-02 00:51:49"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Urano, F, 2010-04-30"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#comment> "The C-terminal domain of PERK has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, causing an arrest in translation. The result is that translation of ER-targeted proteins is halted on ribosomes in the vicinity of activated PERK. The general arrest of translation results in the loss of short-lived proteins such as Cyclin D1, causing an arrest of the cell cycle in G1."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10026192> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/12370288> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/16288713> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/11907036> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/18664456> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/17956313> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_381111> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_18275_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Phosphorylation of eIF2-alpha by PERK"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#eCNumber> "2.7.11"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein1216> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887SmallMolecule2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1727> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Protein6818> .