<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Cooper, HM, 2010-02-16"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#comment> "Edited: Garapati, P V, 2008-07-30 10:24:23"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Garapati, P V, 2008-07-16 14:42:16"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#comment> "The adaptor protein Nck-1 binds to DCC and recruits Rac-1, Cdc42 and their effectors PAK-1 and N-WASP to the activated receptor. Both Cdc42 and Nck-1 are activators of N-WASP. Cdc42 in its active GTP bound form binds to the CRIB domain of N-WASP and this interaction along with PIP2 results in the activation of N-WASP. Nck-1 activate N-WASP via binding of its SH3 domain to the proline rich domain of N-WASP. Nck-1 also possess an SH2 domain that associates directly with activated tyrosine kinase receptors which can phosphorylate N-WASP."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_418874> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_22183_2> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/10995436> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/15040784> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Recruitment and activation of N-WASP by Cdc42"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887SmallMolecule761> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex1492> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein5131> .
<http://www.reactome.org/biopax/48887BiochemicalReaction1222> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex1495> .