. "Authored: Garapati, P V, 2009-02-24 10:31:15"^^ . "Edited: Garapati, P V, 2009-02-24 10:58:20"^^ . "Reviewed: Maness, PF, Walmod, PS, 2009--0-5-"^^ . "Antiparallel NCAM interactions involve trans-interactions of NCAM molecules on opposed cell membranes. Based on structural and functional studies a 'double zipper' model has been proposed to describe these interactions. The first model - the 'flat zipper'- formed between NCAM1 cis-dimers from one cell surface interacting in trans through IgII-IgIII contacts with NCAM1 cis-dimers from another cell surface. The second model - the 'compact zipper'- is formed between NCAM1 cis-dimers from one cell surface interacting in trans through IgI-IgIII and IgII-IgII contacts with cis-dimers from another cell surface.

Abrogation of cis-dimerization inhibits NCAM mediated neurite outgrowth, and cis-dimerization of NCAM1 may be a necessary prerequisite for subsequent trans-interactions."^^ . . . . . . . "NCAM1 trans-homophilic interaction"^^ . . . .