. "Authored: Garapati, P V, 2009-03-23 09:59:28"^^ . "Edited: Garapati, P V, 2009-03-23 10:00:07"^^ . "Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01"^^ . "Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity.
"^^ . . . . . . . "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity"^^ . . . .