. "Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30"^^ . "Reviewed: Trowsdale, J, 2008-02-26 12:02:59"^^ . "PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules."^^ . . . . . . . "Phoshorylation of PECAM-1 by Fyn or Lyn or c-Src"^^ . "2.7.10"^^ . . . . . . .