. "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." . . . "negative regulation of smoothened signaling pathway" . "down regulation of smoothened signaling pathway" . "down-regulation of smoothened signaling pathway" . "downregulation of smoothened signaling pathway" . "inhibition of smoothened signaling pathway" . "negative regulation of hedgehog signaling pathway" . "negative regulation of hh signaling pathway" . "negative regulation of smoothened activity" . "negative regulation of smoothened by patched" . "negative regulation of smoothened receptor activity by patched" . "negative regulation of smoothened signalling pathway" . . . . .