. "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." . . . "DNA topoisomerase II" . "DNA topoisomerase (ATP-hydrolyzing) activity" . "topoisomerase" . "topoisomerase II" . "deoxyribonucleate topoisomerase" . "deoxyribonucleic topoisomerase activity" . "DNA gyrase activity" . "DNA topoisomerase (ATP-hydrolysing)" . "DNA topoisomerase IV activity" . "DNA topoisomerase type II activity" . "DNA-gyrase activity" . "type II DNA topoisomerase activity" . . .