. "Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity." . "The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24)." . . . "Acyl-activating enzyme" . "Long-chain-fatty-acid--CoA ligase" . "Acyl-CoA synthetase" . "Fatty acid thiokinase (long chain)" . "Lignoceroyl-CoA synthase" . "ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA." .