. "These endopeptidases are multi-spanning membrane proteins." . "Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains." . "Important for embryo development in Drosophila melanogaster." . "Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway." . "Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite." . "Belongs to peptidase family S54." . . . "Rhomboid protease" . "Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains." .