. "This enzyme, which operates in the retinal pigment epithelium (RPE), catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle." . "Interaction of the enzyme with the membrane is critical for its enzymatic activity." . . . "Retinoid isomerohydrolase" . "All-trans-retinyl-palmitate hydrolase" . "All-trans-retinylester 11-cis isomerohydrolase" . . "An all-trans-retinyl ester + H(2)O = 11-cis-retinol + a fatty acid." .