. "The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that are implicated in the control of cell growth. A murine cytoplasmic protein that binds specifically to JNK [the JNK interacting protein-1 (JIP-1)] was characterized and cloned. JIP-1 caused cytoplasmic retention of JNK and inhibition of JNK-regulated gene expression. In addition, JIP-1 suppressed the effects of the JNK signaling pathway on cellular proliferation, including transformation by the Bcr-Abl oncogene. This analysis identifies JIP-1 as a specific inhibitor of the JNK signal transduction pathway and establishes protein targeting as a mechanism that regulates signaling by stress-activated MAP kinases." . . . "Science" . "Davis R.J." . "Dickens M." . "Greenberg M.E." . "Cavanagh J." . "Xia Z." . "Rogers J.S." . "Sawyers C.L." . "Raitano A." . "Halpern J.R." . "1997"^^ . "693-696" . "A cytoplasmic inhibitor of the JNK signal transduction pathway." . "277" . "doi:10.1126/science.277.5326.693" .