. "The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology." . . "Proc. Natl. Acad. Sci. U.S.A." . "Kelly D." . "Henrissat B." . "Fitzgerald G.F." . "Mills D." . "Kim J.H." . "Sanchez B." . "Delledonne M." . "van Sinderen D." . "Coutinho P." . "Ventura M." . "Oggioni M." . "Margolles A." . "Ferrarini A." . "Zomer A." . "Turroni F." . "Foroni E." . "Giubellini V." . "Bottacini F." . "Mulder I." . "Bidossi A." . "2010"^^ . "19514-19519" . "Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging." . "107" . "doi:10.1073/pnas.1011100107" .