. "Nedd4-1 is a \"neuronal precursor cell expressed and developmentally downregulated protein\" and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4-1-deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity of Rap2 effector kinases of the TNIK family and promotes dendrite growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons." . . "Neuron" . "Kawabe H." . "Zhang D.E." . "Takeda M." . "Jahn O." . "Nave K.A." . "Kariya K." . "Brose N." . "Rosenmund C." . "Rhee J." . "Umikawa M." . "Goebbels S." . "Malakhova O.A." . "Katsurabayashi S." . "Neeb A." . "Dimova K." . "Mitkovski M." . "Young S.M. Jr." . "2010"^^ . "358-372" . "Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development." . "65" . "doi:10.1016/j.neuron.2010.01.007" .