. "We report the cloning and characterization of DANGER, a novel protein which physiologically binds to inositol 1,4,5-trisphosphate receptors (IP(3)R). DANGER is a membrane-associated protein predicted to contain a partial MAB-21 domain. It is expressed in a wide variety of neuronal cell lineages where it localizes to membranes in the cell periphery together with IP(3)R. DANGER interacts with IP(3)R in vitro and co-immunoprecipitates with IP(3)R from cellular preparations. DANGER robustly enhances Ca(2+)-mediated inhibition of IP(3) RCa(2+) release without affecting IP(3) binding in microsomal assays and inhibits gating in single-channel recordings of IP(3)R. DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed." . . "J. Biol. Chem." . "Snyder S.H." . "Barrow R.K." . "Foskett J.K." . "Patterson R.L." . "Watkins D.N." . "Cheung K.-H." . "van Rossum D.B." . "Burkholder S.G." . "Syrovatkina V." . "Gessell G.S." . "2006"^^ . "37111-37116" . "DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity." . "281" . "doi:10.1074/jbc.M608760200" .