. "Severe acute respiratory syndrome coronavirus (SARS-CoV) 7a is an accessory protein with no known homologues. In this study, we report the interaction of a SARS-CoV 7a and small glutamine-rich tetratricopeptide repeat-containing protein (SGT). SARS-CoV 7a and human SGT interaction was identified using a two-hybrid system screen and confirmed with interaction screens in cell culture and cellular co-localization studies. The SGT domain of interaction was mapped by deletion mutant analysis and results indicated that tetratricopeptide repeat 2 (aa 125-158) was essential for interaction. We also showed that 7a interacted with SARS-CoV structural proteins M (membrane) and E (envelope), which have been shown to be essential for virus-like particle formation. Taken together, our results coupled with data from studies of the interaction between SGT and HIV-1 vpu indicated that SGT could be involved in the life-cycle, possibly assembly of SARS-CoV." . . "Biochem. Biophys. Res. Commun." . "Chou C.-F." . "Shen S." . "Hong W." . "Khan S." . "Fielding B.C." . "Tan T.H.P." . "Lim S.G." . "Tan Y.-J." . "Gunalan V." . "2006"^^ . "1201-1208" . "Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT." . "343" . "doi:10.1016/j.bbrc.2006.03.091" .