. "A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont." . . "Science" . "Donelson J.E." . "Andersson B." . "Peterson J." . "Myler P.J." . "Stuart K.D." . "Nilsson D." . "Embley T.M." . "Badger J." . "Bringaud F." . "Hauser C." . "White O." . "Crabtree J." . "Renauld H." . "Carlton J.M." . "El-Sayed N.M.A." . "Silva J.C." . "Salzberg S.L." . "Caler E." . "Ivens A.C." . "Haas B.J." . "Ghedin E." . "Berriman M." . "Alsmark U.C.M." . "Shallom J." . "Djikeng A." . "Wortman J.R." . "Blandin G." . "Hertz-Fowler C." . "Bartholomeu D.C." . "Pereira-Leal J.B." . "Delcher A.L." . "Hall N." . "Angiuoli S." . "Melville S.E." . "Cerqueira G.C." . "Worthey E.A." . "Aggarwal G." . "Peacock C." . "Tran A.-N." . "Anupama A." . "Cadag E." . "Creasy T." . "Kummerfeld S.K." . "Sundaram J." . "Westenberger S." . "2005"^^ . "404-409" . "Comparative genomics of trypanosomatid parasitic protozoa." . "309" . "doi:10.1126/science.1112181" .