. "Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2. When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli including growth factor withdrawal and endogenous levels of Pim-2 contributed to growth factor-mediated apoptotic resistance. Pim-2 expression maintained cell size and mitochondrial potential independently of the PI3K/Akt/TOR pathway. Pim-2-dependent maintenance of cell size and survival correlated with its ability to maintain rapamycin-resistant phosphorylation of the translational repressor 4E-BP1 and phosphorylation of the BH3 protein BAD. These results establish Pim-2 as a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival." . . "Genes Dev." . "Thompson C.B." . "Chodosh L.A." . "Master S.R." . "Fox C.J." . "Cinalli R.M." . "Hammerman P.S." . "2003"^^ . "1841-1854" . "The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor." . "17" . "doi:10.1101/gad.1105003" .