. "A case-control study was conducted on 1986 Hong Kong women to assess the risk of human papillomavirus (HPV) type 16 variants for cervical neoplasia. In total, 255 women were HPV-16 positive and were analyzed for E6 and E7 sequence variation. Two novel substitutions at E6 (T86I and Q116E) and 1 at E7 (R66W) were found. Most HPV-16 variants were of Asian (50.6%) or European (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. No increased risk was observed for the subclasses European variant and European 350G, which carry a higher risk for invasive cancer in some Western populations. The E7 N29S substitution, reported to have a higher risk in Korean women, was found equally distributed among normal and various degrees of neoplasia. The epidemiology and risk implication of HPV-16 variant infection in Hong Kong differ markedly from other parts of the world." . . . "J. Infect. Dis." . "Li W.W." . "Chan P.K." . "Chan M.Y." . "Lo K.W." . "Lam C.W." . "Cheung T.H." . "Xu L.Y." . "Cheung J.L." . "Cheng A.F." . "2002"^^ . "696-700" . "Human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern China." . "186" . "doi:10.1086/342048" .