. "Plant steroid hormones, known as brassinosteroids (BRs), signal through a plasma membrane localized receptor kinase BRI1. We identified bes1, a semidominant suppressor of bri1, which exhibits constitutive BR response phenotypes including long and bending petioles, curly leaves, accelerated senescence, and constitutive expression of BR-response genes. BES1 accumulates in the nucleus in response to BRs. BES1 is phosphorylated and appears to be destabilized by the glycogen synthase kinase-3 (GSK-3) BIN2, a negative regulator of the BR pathway. These results establish a signaling cascade for BRs with similarities to the Wnt pathway, in which signaling through cell surface receptors leads to inactivation of a GSK-3 allowing accumulation of a nuclear protein that regulates target gene expression." . . "Cell" . "Yin Y." . "Wang Z.Y." . "Li J." . "Yoshida S." . "Chory J." . "Mora-Garcia S." . "Asami T." . "2002"^^ . "181-191" . "BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation." . "109" . "doi:10.1016/S0092-8674(02)00721-3" .