. "The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins." . . . "Microb. Drug Resist." . "Buell G." . "Dopazo J." . "Garcia E." . "Friedli L." . "Garcia-Bustos J.F." . "Feger G." . "Polissi A." . "Humbert Y." . "Caldara F." . "Mendoza A." . "Herrero J." . "Guerrier M." . "Grand-Schenk E." . "Gandin C." . "de Francesco M." . "Peitsch M." . "2001"^^ . "99-125" . "Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate." . "7" . "doi:10.1089/10766290152044995" .