. "Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition." . . "Immunity" . "Kawai T." . "Ogawa T." . "Takeda K." . "Akira S." . "Takada H." . "Hoshino K." . "Takeuchi O." . "Sanjo H." . "1999"^^ . "443-451" . "Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components." . "11" . "doi:10.1016/S1074-7613(00)80119-3" .