. "We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neuroblastoma cells. NNT-1/BSF-3 shows activities typical of IL-6 family members. In vitro, it supports the survival of chicken embryo motor and sympathetic neurons. In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase. NNT-1/BSF-3 is a gp130 activator with B-cell stimulating capability." . . . "Proc. Natl. Acad. Sci. U.S.A." . "Varnum B.C." . "Boone T." . "Simonet W.S." . "McNinch J." . "Guo J." . "Elliott G." . "Chang M.-S." . "Sarmiento U." . "Scully S." . "Senaldi G." . "Freeman D." . "Shaklee C.L." . "Starnes C." . "Lile J." . "Manu F." . "1999"^^ . "11458-11463" . "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family." . "96" . "doi:10.1073/pnas.96.20.11458" .