. "Homomultimer; in vitro and presumably in vivo. Interacts with viral Pr55Gag precursor and host APOBEC3G. The interaction between Vif and APOBEC3G is species-specific, which may play a role in restricting the replication of SIV to their host. Forms an E3 ligase complex by interacting with host CUL5 and elongin BC complex (TCEB1 and TCEB2) (By similarity)." .