. "\"Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.\" [GOC:go_curators]" . . "negative regulation of isotype switching" . "down regulation of isotype switching" . "down-regulation of isotype switching" . "downregulation of isotype switching" . "negative regulation of class switch recombination" . "negative regulation of class switching" . "negative regulation of isotype switch recombination" . . . . . "inhibition of isotype switching" .