. "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.\" [GOC:mah, ISBN:0911910123]" . . "response to estradiol stimulus" . "response to E2 stimulus" . . .