. "\"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.\" [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]" . . "metallopeptidase activity" . "metalloprotease activity" . "metalloproteinase activity" . "Reactome:REACT_100129 \"Notch 4-ligand complex is cleaved to produce NEXT4, Sus scrofa\"" . "Reactome:REACT_100372 \"Notch 1-ligand complex is cleaved to produce NEXT1, Gallus gallus\"" . "Reactome:REACT_100593 \"Cleavage of ATF6-alpha by S2P, Drosophila melanogaster\"" . "Reactome:REACT_100677 \"alpha-secretase cleaves the p75NTR extracellular domain, Rattus norvegicus\"" . "Reactome:REACT_100694 \"Notch 1-ligand complex is cleaved to produce NEXT1, Xenopus tropicalis\"" . "Reactome:REACT_1011 \"Notch 4-ligand complex is cleaved to produce NEXT4, Homo sapiens\"" . "Reactome:REACT_101972 \"Notch 1-ligand complex is cleaved to produce NEXT1, Taeniopygia guttata\"" . "Reactome:REACT_102999 \"Notch 1-ligand complex is cleaved to produce NEXT1, Drosophila melanogaster\"" . "Reactome:REACT_103085 \"Cleavage of ATF6-alpha by S2P, Sus scrofa\"" . "Reactome:REACT_104327 \"Notch 2-ligand complex is cleaved to produce NEXT2, Gallus gallus\"" . "Reactome:REACT_104368 \"Cleavage of ATF6-alpha by S2P, Taeniopygia guttata\"" . "Reactome:REACT_107504 \"alpha-secretase cleaves the p75NTR extracellular domain, Bos taurus\"" . "Reactome:REACT_109423 \"Cleavage of ATF6-alpha by S2P, Bos taurus\"" . "Reactome:REACT_109532 \"Notch 1-ligand complex is cleaved to produce NEXT1, Danio rerio\"" . "Reactome:REACT_114094 \"Notch 3-ligand complex is cleaved to produce NEXT3, Drosophila melanogaster\"" . "Reactome:REACT_115138 \"Notch 4-ligand complex is cleaved to produce NEXT4, Xenopus tropicalis\"" . "Reactome:REACT_13658 \"alpha-secretase cleaves the p75NTR extracellular domain, Homo sapiens\"" . "Reactome:REACT_1552 \"Notch 3-ligand complex is cleaved to produce NEXT3, Homo sapiens\"" . "Reactome:REACT_18387 \"Cleavage of ATF6-alpha by S2P, Homo sapiens\"" . "Reactome:REACT_267 \"Notch 2-ligand complex is cleaved to produce NEXT2, Homo sapiens\"" . "Reactome:REACT_28662 \"Notch 1-ligand complex is cleaved to produce NEXT1, Bos taurus\"" . "Reactome:REACT_29018 \"Notch 4-ligand complex is cleaved to produce NEXT4, Rattus norvegicus\"" . "Reactome:REACT_30292 \"Notch 3-ligand complex is cleaved to produce NEXT3, Danio rerio\"" . "Reactome:REACT_30924 \"Notch 2-ligand complex is cleaved to produce NEXT2, Drosophila melanogaster\"" . "Reactome:REACT_33366 \"Notch 4-ligand complex is cleaved to produce NEXT4, Canis familiaris\"" . "Reactome:REACT_33539 \"alpha-secretase cleaves the p75NTR extracellular domain, Gallus gallus\"" . "Reactome:REACT_33732 \"Notch 4-ligand complex is cleaved to produce NEXT4, Mus musculus\"" . "Reactome:REACT_33852 \"Notch 3-ligand complex is cleaved to produce NEXT3, Rattus norvegicus\"" . "Reactome:REACT_33929 \"Cleavage of ATF6-alpha by S2P, Gallus gallus\"" . "Reactome:REACT_410 \"Notch 1-ligand complex is cleaved to produce NEXT1, Homo sapiens\"" . "Reactome:REACT_77236 \"Notch 4-ligand complex is cleaved to produce NEXT4, Bos taurus\"" . "Reactome:REACT_78816 \"Notch 3-ligand complex is cleaved to produce NEXT3, Bos taurus\"" . "Reactome:REACT_79691 \"alpha-secretase cleaves the p75NTR extracellular domain, Canis familiaris\"" . "Reactome:REACT_79817 \"Notch 2-ligand complex is cleaved to produce NEXT2, Mus musculus\"" . "Reactome:REACT_81981 \"Notch 2-ligand complex is cleaved to produce NEXT2, Bos taurus\"" . "Reactome:REACT_83198 \"Notch 1-ligand complex is cleaved to produce NEXT1, Rattus norvegicus\"" . "Reactome:REACT_83310 \"Notch 2-ligand complex is cleaved to produce NEXT2, Sus scrofa\"" . "Reactome:REACT_83988 \"Notch 2-ligand complex is cleaved to produce NEXT2, Xenopus tropicalis\"" . "Reactome:REACT_89528 \"Cleavage of ATF6-alpha by S2P, Danio rerio\"" . "Reactome:REACT_89928 \"alpha-secretase cleaves the p75NTR extracellular domain, Sus scrofa\"" . "Reactome:REACT_91564 \"Cleavage of ATF6-alpha by S2P, Rattus norvegicus\"" . "Reactome:REACT_92210 \"alpha-secretase cleaves the p75NTR extracellular domain, Danio rerio\"" . "Reactome:REACT_92309 \"Notch 3-ligand complex is cleaved to produce NEXT3, Xenopus tropicalis\"" . "Reactome:REACT_92841 \"alpha-secretase cleaves the p75NTR extracellular domain, Xenopus tropicalis\"" . "Reactome:REACT_93042 \"Cleavage of ATF6-alpha by S2P, Mus musculus\"" . "Reactome:REACT_94705 \"Notch 2-ligand complex is cleaved to produce NEXT2, Danio rerio\"" . "Reactome:REACT_95173 \"Notch 3-ligand complex is cleaved to produce NEXT3, Canis familiaris\"" . "Reactome:REACT_95565 \"Notch 2-ligand complex is cleaved to produce NEXT2, Rattus norvegicus\"" . "Reactome:REACT_96136 \"Notch 1-ligand complex is cleaved to produce NEXT1, Canis familiaris\"" . "Reactome:REACT_96651 \"Cleavage of ATF6-alpha by S2P, Caenorhabditis elegans\"" . "Reactome:REACT_96860 \"Notch 2-ligand complex is cleaved to produce NEXT2, Canis familiaris\"" . "Reactome:REACT_96983 \"Cleavage of ATF6-alpha by S2P, Xenopus tropicalis\"" . "Reactome:REACT_97764 \"alpha-secretase cleaves the p75NTR extracellular domain, Mus musculus\"" . "Reactome:REACT_98127 \"Notch 1-ligand complex is cleaved to produce NEXT1, Mus musculus\"" . "Reactome:REACT_98562 \"Cleavage of ATF6-alpha by S2P, Canis familiaris\"" . "Reactome:REACT_99318 \"Notch 3-ligand complex is cleaved to produce NEXT3, Mus musculus\"" . .