. "\"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.\" [ISBN:0198547684]" . . "MAP kinase kinase activity" . "ATP:protein phosphotransferase (MAPKKK-activated) activity" . "ERK activator kinase activity" . "MAPKK activity" . "mitogen-activated protein kinase kinase activity" . "EC:2.7.11.-" . "MetaCyc:2.7.12.2-RXN" . "Reactome:REACT_21301 \"Activation of p38 alpha/beta MAPK, Homo sapiens\"" . "Reactome:REACT_21350 \"Activation of p38 alpha/beta MAPK, Mus musculus\"" . "Reactome:REACT_75807 \"Activation of p38 MAPK, Homo sapiens\"" . . "MKK6" . "MEK2" . "MKK2" . "MKK4" . "MEK1" . "MKK7" . "MAPKK1" . "MKK" . "MAPKK" . "MAP kinase or ERK kinase activity" . "MAP2K" . "STK27" . "MAP kinase kinase 4 activity" . "MAP kinase kinase 7 activity" . "MEK activity" .