. "\"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).\" [GOC:rn, PMID:7877684, PMID:9841670]" . . "cyclin-dependent protein kinase activity" . "ATP:cyclin phosphotransferase activity" . "CDK activity" . "CDK, catalytic subunit activity" . "cdk-activating kinase activity" . "Cdk-activating protein kinase activity" . "cyclin-dependent protein kinase, intrinsic catalyst activity" . "EC:2.7.11.22" . "MetaCyc:2.7.11.22-RXN" . "Reactome:REACT_100142 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Mus musculus\"" . "Reactome:REACT_100284 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Xenopus tropicalis\"" . "Reactome:REACT_100368 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Mus musculus\"" . "Reactome:REACT_100867 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Canis familiaris\"" . "Reactome:REACT_101084 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Rattus norvegicus\"" . "Reactome:REACT_101412 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Rattus norvegicus\"" . "Reactome:REACT_101652 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Mus musculus\"" . "Reactome:REACT_102726 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Rattus norvegicus\"" . "Reactome:REACT_102799 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Bos taurus\"" . "Reactome:REACT_103183 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Sus scrofa\"" . "Reactome:REACT_103312 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Xenopus tropicalis\"" . "Reactome:REACT_103830 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Bos taurus\"" . "Reactome:REACT_104343 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Danio rerio\"" . "Reactome:REACT_104830 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Canis familiaris\"" . "Reactome:REACT_106008 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Rattus norvegicus\"" . "Reactome:REACT_106596 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Canis familiaris\"" . "Reactome:REACT_107107 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Danio rerio\"" . "Reactome:REACT_107135 \"CDK5 phosphorylates DARPP-32 on Thr75, Rattus norvegicus\"" . "Reactome:REACT_107346 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Rattus norvegicus\"" . "Reactome:REACT_107592 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Danio rerio\"" . "Reactome:REACT_108100 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Sus scrofa\"" . "Reactome:REACT_109124 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Rattus norvegicus\"" . "Reactome:REACT_109419 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Drosophila melanogaster\"" . "Reactome:REACT_109597 \"CDK5 phosphorylates DARPP-32 on Thr75, Canis familiaris\"" . "Reactome:REACT_110505 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Mus musculus\"" . "Reactome:REACT_110542 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Danio rerio\"" . "Reactome:REACT_111206 \"Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex, Homo sapiens\"" . "Reactome:REACT_111248 \"Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex, Homo sapiens\"" . "Reactome:REACT_112082 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Xenopus tropicalis\"" . "Reactome:REACT_112868 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Xenopus tropicalis\"" . "Reactome:REACT_113042 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Saccharomyces cerevisiae\"" . "Reactome:REACT_113645 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Xenopus tropicalis\"" . "Reactome:REACT_113808 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Schizosaccharomyces pombe\"" . "Reactome:REACT_113866 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe\"" . "Reactome:REACT_115193 \"CDK5 phosphorylates DARPP-32 on Thr75, Xenopus tropicalis\"" . "Reactome:REACT_115457 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae\"" . "Reactome:REACT_15365 \"CDK5 phosphorylates DARPP-32 on Thr75, Homo sapiens\"" . "Reactome:REACT_15543 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Homo sapiens\"" . "Reactome:REACT_1627 \"Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes, Homo sapiens\"" . "Reactome:REACT_1882 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Homo sapiens\"" . "Reactome:REACT_28043 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Rattus norvegicus\"" . "Reactome:REACT_28206 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Mus musculus\"" . "Reactome:REACT_28927 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Xenopus tropicalis\"" . "Reactome:REACT_29737 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Bos taurus\"" . "Reactome:REACT_30547 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Mus musculus\"" . "Reactome:REACT_30560 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Mus musculus\"" . "Reactome:REACT_30857 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Canis familiaris\"" . "Reactome:REACT_30946 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Taeniopygia guttata\"" . "Reactome:REACT_31143 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Arabidopsis thaliana\"" . "Reactome:REACT_32944 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Xenopus tropicalis\"" . "Reactome:REACT_33000 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Bos taurus\"" . "Reactome:REACT_33255 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Oryza sativa\"" . "Reactome:REACT_33633 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Mus musculus\"" . "Reactome:REACT_33864 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Bos taurus\"" . "Reactome:REACT_34028 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Danio rerio\"" . "Reactome:REACT_406 \"Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes, Homo sapiens\"" . "Reactome:REACT_46105 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Sus scrofa\"" . "Reactome:REACT_55912 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Canis familiaris\"" . "Reactome:REACT_6338 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Homo sapiens\"" . "Reactome:REACT_6721 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Homo sapiens\"" . "Reactome:REACT_68077 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Canis familiaris\"" . "Reactome:REACT_6811 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Homo sapiens\"" . "Reactome:REACT_6891 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Homo sapiens\"" . "Reactome:REACT_6942 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Homo sapiens\"" . "Reactome:REACT_77008 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Mus musculus\"" . "Reactome:REACT_77473 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Bos taurus\"" . "Reactome:REACT_77863 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Rattus norvegicus\"" . "Reactome:REACT_78910 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Xenopus tropicalis\"" . "Reactome:REACT_80990 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Drosophila melanogaster\"" . "Reactome:REACT_81918 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Drosophila melanogaster\"" . "Reactome:REACT_82302 \"CDK5 phosphorylates DARPP-32 on Thr75, Mus musculus\"" . "Reactome:REACT_82539 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Drosophila melanogaster\"" . "Reactome:REACT_82578 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Danio rerio\"" . "Reactome:REACT_83958 \"CDK5 phosphorylates DARPP-32 on Thr75, Bos taurus\"" . "Reactome:REACT_84020 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Xenopus tropicalis\"" . "Reactome:REACT_84061 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Rattus norvegicus\"" . "Reactome:REACT_84295 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Rattus norvegicus\"" . "Reactome:REACT_852 \"Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes, Homo sapiens\"" . "Reactome:REACT_85707 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Canis familiaris\"" . "Reactome:REACT_85853 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Rattus norvegicus\"" . "Reactome:REACT_86936 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Danio rerio\"" . "Reactome:REACT_88269 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Sus scrofa\"" . "Reactome:REACT_88622 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Bos taurus\"" . "Reactome:REACT_89028 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Canis familiaris\"" . "Reactome:REACT_89106 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Bos taurus\"" . "Reactome:REACT_89375 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Danio rerio\"" . "Reactome:REACT_89502 \"Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Bos taurus\"" . "Reactome:REACT_8993 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Homo sapiens\"" . "Reactome:REACT_8995 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Homo sapiens\"" . "Reactome:REACT_8998 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Homo sapiens\"" . "Reactome:REACT_9023 \"Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Homo sapiens\"" . "Reactome:REACT_91084 \"Cyclin E:Cdk2-mediated phosphorylation of Rb, Sus scrofa\"" . "Reactome:REACT_91609 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Danio rerio\"" . "Reactome:REACT_92060 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Bos taurus\"" . "Reactome:REACT_93696 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Danio rerio\"" . "Reactome:REACT_93979 \"Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Mus musculus\"" . "Reactome:REACT_94092 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Xenopus tropicalis\"" . "Reactome:REACT_96284 \"Free APC/C phosphorylated by Cyclin B:Cdc2, Canis familiaris\"" . "Reactome:REACT_96884 \"CDK5 phosphorylates DARPP-32 on Thr75, Danio rerio\"" . "Reactome:REACT_96907 \"Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Danio rerio\"" . "Reactome:REACT_98018 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Xenopus tropicalis\"" . "Reactome:REACT_98320 \"Cyclin B/Cdk1 mediate phosphorylation of NuMA, Canis familiaris\"" . "Reactome:REACT_98605 \"Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Bos taurus\"" . "Reactome:REACT_99005 \"Phosphorylation of Cdh1 by Cyclin A:Cdk2, Gallus gallus\"" . "Reactome:REACT_99017 \"Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Canis familiaris\"" . "Reactome:REACT_99668 \"Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Mus musculus\"" . . "CDK" . "cdc2 kinase activity" . "cyclin D-cdk6 kinase activity" . "cyclin D-dependent kinase activity" . "cyclin E kinase activity" . "cyclin-A associated kinase activity" . "cyclin-dependent kinase 6 activity" . "cyclin-dependent kinase-2 activity" . "cyclin-dependent kinase-4 activity" . "D-type cyclin kinase activity" . "neuronal cdc2-like kinase activity" . "cyclin-dependent kinase activity" .