. "\"Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).\" [EC:1.14.13.13, RHEA:20576]" . . "calcidiol 1-monooxygenase activity" . "25-hydroxy D3-1alpha-hydroxylase activity" . "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" . "25-hydroxycholecalciferol 1-hydroxylase activity" . "25-hydroxycholecalciferol 1-monooxygenase activity" . "25-hydroxycholecalciferol 1alpha-hydroxylase activity" . "25-hydroxycholecalciferol-1-hydroxylase activity" . "25-hydroxyvitamin D-1 alpha hydroxylase activity" . "25-hydroxyvitamin D3 1alpha-hydroxylase activity" . "25-OHD-1 alpha-hydroxylase activity" . "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" . "EC:1.14.13.13" . "KEGG:R03610" . "MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN" . "Reactome:REACT_102929 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Danio rerio\"" . "Reactome:REACT_106826 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Drosophila melanogaster\"" . "Reactome:REACT_110331 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Canis familiaris\"" . "Reactome:REACT_13628 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Homo sapiens\"" . "Reactome:REACT_83168 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Xenopus tropicalis\"" . "Reactome:REACT_84663 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Bos taurus\"" . "Reactome:REACT_93300 \"Further hydroxylation of calcidiol in kidney to form calcitriol, Mus musculus\"" . "RHEA:20576" . . "1-hydroxylase-25-hydroxyvitamin D3 activity" . "cytochrome P450 CYP27B" .