. "\"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).\" [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]" . . "serine-type endopeptidase activity" . "Reactome:REACT_103434 \"Processing of Proinsulin to Insulin, Rattus norvegicus\"" . "Reactome:REACT_104808 \"Processing of Proinsulin to Insulin, Taeniopygia guttata\"" . "Reactome:REACT_15374 \"Processing of Proinsulin to Insulin, Homo sapiens\"" . "Reactome:REACT_30489 \"Processing of Proinsulin to Insulin, Danio rerio\"" . "Reactome:REACT_31280 \"Processing of Proinsulin to Insulin, Xenopus tropicalis\"" . "Reactome:REACT_34275 \"Processing of Proinsulin to Insulin, Bos taurus\"" . "Reactome:REACT_76942 \"Processing of Proinsulin to Insulin, Canis familiaris\"" . "Reactome:REACT_85582 \"Processing of Proinsulin to Insulin, Mus musculus\"" . "Reactome:REACT_93274 \"Processing of Proinsulin to Insulin, Gallus gallus\"" . "EC:3.4.21" . "Reactome:REACT_100031 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Danio rerio\"" . "Reactome:REACT_100125 \"Granzyme-B activates BID by cleavage, Mus musculus\"" . "Reactome:REACT_100194 \"Thrombin-mediated activation of Proteinase-activated receptors, Taeniopygia guttata\"" . "Reactome:REACT_100271 \"pro-factor IX -> factor IX + factor IX propeptide, Rattus norvegicus\"" . "Reactome:REACT_100321 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Rattus norvegicus\"" . "Reactome:REACT_10058 \"Part of pro-beta-NGF is processed to mature beta-NGF, Homo sapiens\"" . "Reactome:REACT_100669 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Rattus norvegicus\"" . "Reactome:REACT_100764 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Gallus gallus\"" . "Reactome:REACT_100842 \"pro-factor VII -> factor VII + factor VII propeptide, Canis familiaris\"" . "Reactome:REACT_100919 \"Formation of alternate C5 convertase, Mus musculus\"" . "Reactome:REACT_100938 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Canis familiaris\"" . "Reactome:REACT_101008 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Rattus norvegicus\"" . "Reactome:REACT_101012 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Danio rerio\"" . "Reactome:REACT_101033 \"Processing of Proglucagon to Glucagon-like Peptide-1, Rattus norvegicus\"" . "Reactome:REACT_101265 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Gallus gallus\"" . "Reactome:REACT_101293 \"pro-factor IX -> factor IX + factor IX propeptide, Mus musculus\"" . "Reactome:REACT_101358 \"Notch 1 precursor cleaved to form a heterodimer, Rattus norvegicus\"" . "Reactome:REACT_101408 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Bos taurus\"" . "Reactome:REACT_101486 \"Granzyme-B activates BID by cleavage, Canis familiaris\"" . "Reactome:REACT_101710 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Bos taurus\"" . "Reactome:REACT_102047 \"Processing of preproGLP-1 to proGLP-1, Xenopus tropicalis\"" . "Reactome:REACT_102222 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Danio rerio\"" . "Reactome:REACT_102226 \"factor Va -> factor Vi, Taeniopygia guttata\"" . "Reactome:REACT_102247 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Sus scrofa\"" . "Reactome:REACT_102300 \"pro-factor VII -> factor VII + factor VII propeptide, Gallus gallus\"" . "Reactome:REACT_102318 \"Processing of preproGLP-1 to proGLP-1, Mus musculus\"" . "Reactome:REACT_102435 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Canis familiaris\"" . "Reactome:REACT_102450 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Bos taurus\"" . "Reactome:REACT_102555 \"Cleavage of ATF6-alpha by S1P, Drosophila melanogaster\"" . "Reactome:REACT_102564 \"Notch 1 precursor cleaved to form a heterodimer, Mus musculus\"" . "Reactome:REACT_102660 \"Factor D cleaves C3b-bound Factor B, Danio rerio\"" . "Reactome:REACT_102717 \"factor Va -> factor Vi, Bos taurus\"" . "Reactome:REACT_102762 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Mus musculus\"" . "Reactome:REACT_103193 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Taeniopygia guttata\"" . "Reactome:REACT_103297 \"Extracellular processing of novel PDGFs, Gallus gallus\"" . "Reactome:REACT_103317 \"protein C -> activated protein C + protein C heavy chain activation peptide, Bos taurus\"" . "Reactome:REACT_103386 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Xenopus tropicalis\"" . "Reactome:REACT_103529 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Canis familiaris\"" . "Reactome:REACT_103532 \"Processing of classical PDGFs, Gallus gallus\"" . "Reactome:REACT_103534 \"Latent TGF-beta1 is cleaved by furin, Xenopus tropicalis\"" . "Reactome:REACT_103821 \"pro-factor X -> factor X + factor X propeptide, Gallus gallus\"" . "Reactome:REACT_104063 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Sus scrofa\"" . "Reactome:REACT_104096 \"Processing of preproGLP-1 to proGLP-1, Canis familiaris\"" . "Reactome:REACT_104436 \"pro-factor IX -> factor IX + factor IX propeptide, Gallus gallus\"" . "Reactome:REACT_104461 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Danio rerio\"" . "Reactome:REACT_104513 \"Conversion of C2 into C2a and C2b, Mus musculus\"" . "Reactome:REACT_104582 \"Part of pro-beta-NGF is processed to mature beta-NGF, Sus scrofa\"" . "Reactome:REACT_104633 \"factor Va -> factor Vi, Mus musculus\"" . "Reactome:REACT_104789 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Taeniopygia guttata\"" . "Reactome:REACT_104872 \"Cleavage of ATF6-alpha by S1P, Gallus gallus\"" . "Reactome:REACT_104930 \"pro-factor IX -> factor IX + factor IX propeptide, Sus scrofa\"" . "Reactome:REACT_105381 \"Notch 1 precursor cleaved to form a heterodimer, Danio rerio\"" . "Reactome:REACT_105667 \"Processing of Proglucagon to Glucagon-like Peptide-1, Canis familiaris\"" . "Reactome:REACT_105786 \"Processing of Proglucagon to Glucagon-like Peptide-1, Taeniopygia guttata\"" . "Reactome:REACT_106150 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Sus scrofa\"" . "Reactome:REACT_106201 \"Processing of proGIP to GIP, Rattus norvegicus\"" . "Reactome:REACT_106288 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Rattus norvegicus\"" . "Reactome:REACT_106360 \"pro-factor IX -> factor IX + factor IX propeptide, Danio rerio\"" . "Reactome:REACT_106442 \"Cleavage of the Signal Peptide of Preproghrelin, Bos taurus\"" . "Reactome:REACT_1065 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Homo sapiens\"" . "Reactome:REACT_106545 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Canis familiaris\"" . "Reactome:REACT_106587 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Mus musculus\"" . "Reactome:REACT_106621 \"Notch 3 precursor cleaved to form a heterodimer, Canis familiaris\"" . "Reactome:REACT_106696 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Canis familiaris\"" . "Reactome:REACT_106726 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Taeniopygia guttata\"" . "Reactome:REACT_106877 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Danio rerio\"" . "Reactome:REACT_106997 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Rattus norvegicus\"" . "Reactome:REACT_107059 \"pro-factor IX -> factor IX + factor IX propeptide, Canis familiaris\"" . "Reactome:REACT_1071 \"factor Va -> factor Vi, Homo sapiens\"" . "Reactome:REACT_107173 \"pro-protein Z -> protein Z + protein Z propeptide, Rattus norvegicus\"" . "Reactome:REACT_107386 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Sus scrofa\"" . "Reactome:REACT_107456 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Sus scrofa\"" . "Reactome:REACT_107494 \"Processing of preproGLP-1 to proGLP-1, Sus scrofa\"" . "Reactome:REACT_107597 \"Granzyme-B activates BID by cleavage, Sus scrofa\"" . "Reactome:REACT_107831 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Gallus gallus\"" . "Reactome:REACT_107946 \"pro-protein S -> protein S + protein S propeptide, Sus scrofa\"" . "Reactome:REACT_108231 \"Activation of C1R, Sus scrofa\"" . "Reactome:REACT_108261 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Bos taurus\"" . "Reactome:REACT_108266 \"Cleavage of ATF6-alpha by S1P, Canis familiaris\"" . "Reactome:REACT_108267 \"Processing of proGIP to GIP, Canis familiaris\"" . "Reactome:REACT_108525 \"pro-factor VII -> factor VII + factor VII propeptide, Danio rerio\"" . "Reactome:REACT_108824 \"Extracellular processing of novel PDGFs, Canis familiaris\"" . "Reactome:REACT_108968 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Mus musculus\"" . "Reactome:REACT_109057 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Danio rerio\"" . "Reactome:REACT_109058 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Canis familiaris\"" . "Reactome:REACT_109495 \"Notch 2 precursor cleaved to form a heterodimer, Drosophila melanogaster\"" . "Reactome:REACT_109499 \"Processing of Proglucagon to Glucagon-like Peptide-1, Sus scrofa\"" . "Reactome:REACT_1097 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Homo sapiens\"" . "Reactome:REACT_109879 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Canis familiaris\"" . "Reactome:REACT_109955 \"Cleavage of ATF6-alpha by S1P, Taeniopygia guttata\"" . "Reactome:REACT_110020 \"Thrombin-mediated activation of Proteinase-activated receptors, Mus musculus\"" . "Reactome:REACT_110040 \"pro-factor IX -> factor IX + factor IX propeptide, Taeniopygia guttata\"" . "Reactome:REACT_110135 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Gallus gallus\"" . "Reactome:REACT_110160 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Taeniopygia guttata\"" . "Reactome:REACT_110219 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Mus musculus\"" . "Reactome:REACT_110269 \"factor VII -> factor VIIa, Danio rerio\"" . "Reactome:REACT_110434 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Mus musculus\"" . "Reactome:REACT_110438 \"Part of pro-beta-NGF is processed to mature beta-NGF, Mus musculus\"" . "Reactome:REACT_110522 \"Notch 4 precursor cleaved to form a heterodimer, Bos taurus\"" . "Reactome:REACT_110563 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Danio rerio\"" . "Reactome:REACT_110705 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Taeniopygia guttata\"" . "Reactome:REACT_110746 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Mus musculus\"" . "Reactome:REACT_110798 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Bos taurus\"" . "Reactome:REACT_110898 \"Extracellular processing of novel PDGFs, Mus musculus\"" . "Reactome:REACT_111180 \"Cleavage of Nodal Proprotein, Mus musculus\"" . "Reactome:REACT_111228 \"Cleavage of NODAL Proprotein, Homo sapiens\"" . "Reactome:REACT_1117 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Homo sapiens\"" . "Reactome:REACT_112053 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Canis familiaris\"" . "Reactome:REACT_112058 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Xenopus tropicalis\"" . "Reactome:REACT_112131 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Gallus gallus\"" . "Reactome:REACT_11214 \"The signal peptide is excised from pre-pro-NGF, Mus musculus\"" . "Reactome:REACT_112143 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Bos taurus\"" . "Reactome:REACT_112184 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Xenopus tropicalis\"" . "Reactome:REACT_112194 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Danio rerio\"" . "Reactome:REACT_112204 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Sus scrofa\"" . "Reactome:REACT_112253 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Danio rerio\"" . "Reactome:REACT_112277 \"Granzyme-B activates BID by cleavage, Xenopus tropicalis\"" . "Reactome:REACT_112440 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Xenopus tropicalis\"" . "Reactome:REACT_112453 \"Notch 3 precursor cleaved to form a heterodimer, Drosophila melanogaster\"" . "Reactome:REACT_112489 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Bos taurus\"" . "Reactome:REACT_112510 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Rattus norvegicus\"" . "Reactome:REACT_112675 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Xenopus tropicalis\"" . "Reactome:REACT_1127 \"Notch 1 precursor cleaved to form a heterodimer, Homo sapiens\"" . "Reactome:REACT_112763 \"Notch 4 precursor cleaved to form a heterodimer, Xenopus tropicalis\"" . "Reactome:REACT_112800 \"Latent TGF-beta1 is cleaved by furin, Caenorhabditis elegans\"" . "Reactome:REACT_112843 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Xenopus tropicalis\"" . "Reactome:REACT_113002 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Rattus norvegicus\"" . "Reactome:REACT_113239 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Gallus gallus\"" . "Reactome:REACT_113539 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Taeniopygia guttata\"" . "Reactome:REACT_113596 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Xenopus tropicalis\"" . "Reactome:REACT_113760 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Sus scrofa\"" . "Reactome:REACT_113831 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Xenopus tropicalis\"" . "Reactome:REACT_114057 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Sus scrofa\"" . "Reactome:REACT_114147 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Mus musculus\"" . "Reactome:REACT_114209 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Canis familiaris\"" . "Reactome:REACT_114347 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Xenopus tropicalis\"" . "Reactome:REACT_114464 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Xenopus tropicalis\"" . "Reactome:REACT_115043 \"Latent TGF-beta1 is cleaved by furin, Drosophila melanogaster\"" . "Reactome:REACT_115078 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Danio rerio\"" . "Reactome:REACT_115086 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Taeniopygia guttata\"" . "Reactome:REACT_115256 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Mus musculus\"" . "Reactome:REACT_115338 \"protein C -> activated protein C + protein C heavy chain activation peptide, Xenopus tropicalis\"" . "Reactome:REACT_115742 \"Signal peptide cleavage from ribosome-associated nascent protein, Homo sapiens\"" . "Reactome:REACT_118086 \"Signal peptide cleavage from ribosome-associated nascent protein, Oryza sativa\"" . "Reactome:REACT_118100 \"Signal peptide cleavage from ribosome-associated nascent protein, Xenopus tropicalis\"" . "Reactome:REACT_118128 \"Signal peptide cleavage from ribosome-associated nascent protein, Arabidopsis thaliana\"" . "Reactome:REACT_118174 \"Signal peptide cleavage from ribosome-associated nascent protein, Caenorhabditis elegans\"" . "Reactome:REACT_118183 \"Signal peptide cleavage from ribosome-associated nascent protein, Danio rerio\"" . "Reactome:REACT_118198 \"Signal peptide cleavage from ribosome-associated nascent protein, Drosophila melanogaster\"" . "Reactome:REACT_118250 \"Signal peptide cleavage from ribosome-associated nascent protein, Dictyostelium discoideum\"" . "Reactome:REACT_118264 \"Signal peptide cleavage from ribosome-associated nascent protein, Taeniopygia guttata\"" . "Reactome:REACT_118287 \"Signal peptide cleavage from ribosome-associated nascent protein, Gallus gallus\"" . "Reactome:REACT_118304 \"Signal peptide cleavage from ribosome-associated nascent protein, Canis familiaris\"" . "Reactome:REACT_118357 \"Signal peptide cleavage from ribosome-associated nascent protein, Plasmodium falciparum\"" . "Reactome:REACT_118392 \"Signal peptide cleavage from ribosome-associated nascent protein, Mus musculus\"" . "Reactome:REACT_118422 \"Signal peptide cleavage from ribosome-associated nascent protein, Rattus norvegicus\"" . "Reactome:REACT_1243 \"Notch 3 precursor cleaved to form a heterodimer, Homo sapiens\"" . "Reactome:REACT_1423 \"pro-factor VII -> factor VII + factor VII propeptide, Homo sapiens\"" . "Reactome:REACT_1446 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Homo sapiens\"" . "Reactome:REACT_1455 \"factor XII -> factor XIIa, Homo sapiens\"" . "Reactome:REACT_1456 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Homo sapiens\"" . "Reactome:REACT_1500 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Homo sapiens\"" . "Reactome:REACT_15308 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Homo sapiens\"" . "Reactome:REACT_1535 \"pro-protein Z -> protein Z + protein Z propeptide, Homo sapiens\"" . "Reactome:REACT_1536 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Homo sapiens\"" . "Reactome:REACT_15373 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Homo sapiens\"" . "Reactome:REACT_15393 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Homo sapiens\"" . "Reactome:REACT_15465 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Homo sapiens\"" . "Reactome:REACT_158 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Homo sapiens\"" . "Reactome:REACT_1581 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Homo sapiens\"" . "Reactome:REACT_1610 \"Granzyme-B activates BID by cleavage, Homo sapiens\"" . "Reactome:REACT_1644 \"pro-factor X -> factor X + factor X propeptide, Homo sapiens\"" . "Reactome:REACT_1668 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Homo sapiens\"" . "Reactome:REACT_1676 \"Notch 2 precursor cleaved to form a heterodimer, Homo sapiens\"" . "Reactome:REACT_16891 \"Extracellular processing of novel PDGFs, Homo sapiens\"" . "Reactome:REACT_17059 \"Processing of classical PDGFs, Homo sapiens\"" . "Reactome:REACT_18401 \"Cleavage of ATF6-alpha by S1P, Homo sapiens\"" . "Reactome:REACT_1860 \"pro-protein S -> protein S + protein S propeptide, Homo sapiens\"" . "Reactome:REACT_19170 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Homo sapiens\"" . "Reactome:REACT_19296 \"Cleavage of the Signal Peptide of Preproghrelin, Homo sapiens\"" . "Reactome:REACT_2004 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Homo sapiens\"" . "Reactome:REACT_2028 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Homo sapiens\"" . "Reactome:REACT_20669 \"Cleavage of the Signal Peptide of Preprolactin by Signal Peptidase (Canis), Bos taurus\"" . "Reactome:REACT_2073 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Homo sapiens\"" . "Reactome:REACT_2114 \"Notch 4 precursor cleaved to form a heterodimer, Homo sapiens\"" . "Reactome:REACT_214 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Homo sapiens\"" . "Reactome:REACT_2146 \"pro-protein C -> protein C + protein C propeptide, Homo sapiens\"" . "Reactome:REACT_217 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Homo sapiens\"" . "Reactome:REACT_2226 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Homo sapiens\"" . "Reactome:REACT_23836 \"Processing of ProGip to Gip (mouse), Mus musculus\"" . "Reactome:REACT_23854 \"Processing of Proglucagon to Glucagon-like Peptide-1 (7-37) (mouse), Mus musculus\"" . "Reactome:REACT_23859 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Homo sapiens\"" . "Reactome:REACT_23880 \"Processing of proGIP to GIP, Homo sapiens\"" . "Reactome:REACT_23888 \"Processing of preproGIP to proGIP, Homo sapiens\"" . "Reactome:REACT_23895 \"Processing of Proglucagon to Glucagon-like Peptide-1, Homo sapiens\"" . "Reactome:REACT_23907 \"Processing of preproGLP-1 to proGLP-1, Homo sapiens\"" . "Reactome:REACT_23940 \"Processing of Proglucagon to Glucagon-like Peptide-1 (7-36) (mouse), Mus musculus\"" . "Reactome:REACT_23981 \"Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Homo sapiens\"" . "Reactome:REACT_245 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Homo sapiens\"" . "Reactome:REACT_28116 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Mus musculus\"" . "Reactome:REACT_28152 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Sus scrofa\"" . "Reactome:REACT_28164 \"Part of pro-beta-NGF is processed to mature beta-NGF, Rattus norvegicus\"" . "Reactome:REACT_28332 \"Cleavage of ATF6-alpha by S1P, Danio rerio\"" . "Reactome:REACT_28354 \"Conversion of C4 into C4a and C4b, Bos taurus\"" . "Reactome:REACT_28382 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Canis familiaris\"" . "Reactome:REACT_28391 \"pro-protein C -> protein C + protein C propeptide, Taeniopygia guttata\"" . "Reactome:REACT_28533 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Canis familiaris\"" . "Reactome:REACT_28597 \"protein C -> activated protein C + protein C heavy chain activation peptide, Rattus norvegicus\"" . "Reactome:REACT_28631 \"Processing of classical PDGFs, Xenopus tropicalis\"" . "Reactome:REACT_28673 \"Notch 2 precursor cleaved to form a heterodimer, Gallus gallus\"" . "Reactome:REACT_28723 \"protein C -> activated protein C + protein C heavy chain activation peptide, Canis familiaris\"" . "Reactome:REACT_28758 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Gallus gallus\"" . "Reactome:REACT_28923 \"Activation of C1S, Mus musculus\"" . "Reactome:REACT_29316 \"pro-factor X -> factor X + factor X propeptide, Xenopus tropicalis\"" . "Reactome:REACT_29593 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Bos taurus\"" . "Reactome:REACT_29596 \"Extracellular processing of novel PDGFs, Taeniopygia guttata\"" . "Reactome:REACT_29653 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Gallus gallus\"" . "Reactome:REACT_29792 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Canis familiaris\"" . "Reactome:REACT_29846 \"pro-factor X -> factor X + factor X propeptide, Taeniopygia guttata\"" . "Reactome:REACT_29855 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Danio rerio\"" . "Reactome:REACT_29954 \"Activation of C1R, Xenopus tropicalis\"" . "Reactome:REACT_30094 \"factor V -> factor Va + factor V activation peptide, Taeniopygia guttata\"" . "Reactome:REACT_30232 \"Cleavage of the Signal Peptide of Preproghrelin, Mus musculus\"" . "Reactome:REACT_30422 \"Notch 4 precursor cleaved to form a heterodimer, Mus musculus\"" . "Reactome:REACT_30505 \"Processing of proGIP to GIP, Bos taurus\"" . "Reactome:REACT_31158 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Taeniopygia guttata\"" . "Reactome:REACT_31164 \"pro-protein S -> protein S + protein S propeptide, Mus musculus\"" . "Reactome:REACT_31419 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Sus scrofa\"" . "Reactome:REACT_31420 \"Part of pro-beta-NGF is processed to mature beta-NGF, Taeniopygia guttata\"" . "Reactome:REACT_31582 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Bos taurus\"" . "Reactome:REACT_31786 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Bos taurus\"" . "Reactome:REACT_31846 \"pro-protein S -> protein S + protein S propeptide, Danio rerio\"" . "Reactome:REACT_32001 \"Notch 2 precursor cleaved to form a heterodimer, Canis familiaris\"" . "Reactome:REACT_32108 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Canis familiaris\"" . "Reactome:REACT_32118 \"factor XII -> factor XIIa, Rattus norvegicus\"" . "Reactome:REACT_32241 \"Processing of preproGLP-1 to proGLP-1, Rattus norvegicus\"" . "Reactome:REACT_32341 \"Activation of C1R, Bos taurus\"" . "Reactome:REACT_32350 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Bos taurus\"" . "Reactome:REACT_32753 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Rattus norvegicus\"" . "Reactome:REACT_32785 \"Processing of classical PDGFs, Sus scrofa\"" . "Reactome:REACT_32919 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Danio rerio\"" . "Reactome:REACT_32975 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Mus musculus\"" . "Reactome:REACT_32977 \"Thrombin-mediated activation of Proteinase-activated receptors, Xenopus tropicalis\"" . "Reactome:REACT_33012 \"Processing of classical PDGFs, Mus musculus\"" . "Reactome:REACT_33038 \"Activation of C1S, Rattus norvegicus\"" . "Reactome:REACT_33127 \"Cleavage of C3 by C3 convertases, Sus scrofa\"" . "Reactome:REACT_33210 \"Latent TGF-beta1 is cleaved by furin, Canis familiaris\"" . "Reactome:REACT_33288 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Rattus norvegicus\"" . "Reactome:REACT_33326 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Gallus gallus\"" . "Reactome:REACT_33367 \"Thrombin-mediated activation of Proteinase-activated receptors, Bos taurus\"" . "Reactome:REACT_33418 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Canis familiaris\"" . "Reactome:REACT_33841 \"pro-protein Z -> protein Z + protein Z propeptide, Mus musculus\"" . "Reactome:REACT_33939 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Rattus norvegicus\"" . "Reactome:REACT_33975 \"Extracellular processing of novel PDGFs, Bos taurus\"" . "Reactome:REACT_34064 \"factor V -> factor Va + factor V activation peptide, Sus scrofa\"" . "Reactome:REACT_34085 \"factor VII -> factor VIIa, Rattus norvegicus\"" . "Reactome:REACT_34137 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Bos taurus\"" . "Reactome:REACT_34159 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Mus musculus\"" . "Reactome:REACT_34262 \"Conversion of C2 into C2a and C2b, Gallus gallus\"" . "Reactome:REACT_34474 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Mus musculus\"" . "Reactome:REACT_34555 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Danio rerio\"" . "Reactome:REACT_34558 \"Processing of Proglucagon to Glucagon-like Peptide-1, Gallus gallus\"" . "Reactome:REACT_374 \"protein C -> activated protein C + protein C heavy chain activation peptide, Homo sapiens\"" . "Reactome:REACT_37926 \"Processing of preproGLP-1 to proGLP-1, Gallus gallus\"" . "Reactome:REACT_41363 \"factor VII -> factor VIIa, Canis familiaris\"" . "Reactome:REACT_41656 \"Thrombin-mediated activation of Proteinase-activated receptors, Canis familiaris\"" . "Reactome:REACT_420 \"pro-factor IX -> factor IX + factor IX propeptide, Homo sapiens\"" . "Reactome:REACT_493 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Homo sapiens\"" . "Reactome:REACT_547 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Homo sapiens\"" . "Reactome:REACT_598 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Homo sapiens\"" . "Reactome:REACT_59890 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Gallus gallus\"" . "Reactome:REACT_64320 \"factor V -> factor Va + factor V activation peptide, Bos taurus\"" . "Reactome:REACT_65367 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Canis familiaris\"" . "Reactome:REACT_6931 \"Latent TGF-beta1 is cleaved by furin, Homo sapiens\"" . "Reactome:REACT_708 \"factor V -> factor Va + factor V activation peptide, Homo sapiens\"" . "Reactome:REACT_72 \"Thrombin-mediated activation of Proteinase-activated receptors, Homo sapiens\"" . "Reactome:REACT_729 \"fibrin multimer, crosslinked -> fibrin digestion products (plasmin), Homo sapiens\"" . "Reactome:REACT_739 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Homo sapiens\"" . "Reactome:REACT_75563 \"pro-factor X -> factor X + factor X propeptide, Rattus norvegicus\"" . "Reactome:REACT_76945 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Mus musculus\"" . "Reactome:REACT_76972 \"factor V -> factor Va + factor V activation peptide, Gallus gallus\"" . "Reactome:REACT_77116 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Mus musculus\"" . "Reactome:REACT_77208 \"pro-factor X -> factor X + factor X propeptide, Mus musculus\"" . "Reactome:REACT_77419 \"factor V -> factor Va + factor V activation peptide, Mus musculus\"" . "Reactome:REACT_77528 \"Notch 3 precursor cleaved to form a heterodimer, Mus musculus\"" . "Reactome:REACT_77756 \"pro-protein C -> protein C + protein C propeptide, Xenopus tropicalis\"" . "Reactome:REACT_77779 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Gallus gallus\"" . "Reactome:REACT_77797 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Taeniopygia guttata\"" . "Reactome:REACT_77805 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Bos taurus\"" . "Reactome:REACT_77894 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Mus musculus\"" . "Reactome:REACT_77968 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Danio rerio\"" . "Reactome:REACT_78022 \"pro-factor VII -> factor VII + factor VII propeptide, Xenopus tropicalis\"" . "Reactome:REACT_78188 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Sus scrofa\"" . "Reactome:REACT_78229 \"factor Va -> factor Vi, Rattus norvegicus\"" . "Reactome:REACT_78374 \"pro-protein C -> protein C + protein C propeptide, Rattus norvegicus\"" . "Reactome:REACT_78406 \"Thrombin-mediated activation of Proteinase-activated receptors, Danio rerio\"" . "Reactome:REACT_78477 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Sus scrofa\"" . "Reactome:REACT_78734 \"Extracellular processing of novel PDGFs, Sus scrofa\"" . "Reactome:REACT_78776 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Danio rerio\"" . "Reactome:REACT_78830 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Sus scrofa\"" . "Reactome:REACT_79061 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Bos taurus\"" . "Reactome:REACT_79079 \"Latent TGF-beta1 is cleaved by furin, Danio rerio\"" . "Reactome:REACT_79192 \"Activation of C1S, Sus scrofa\"" . "Reactome:REACT_79426 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Sus scrofa\"" . "Reactome:REACT_79431 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Gallus gallus\"" . "Reactome:REACT_7948 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Homo sapiens\"" . "Reactome:REACT_79486 \"Cleavage of C3 by C3 convertases, Canis familiaris\"" . "Reactome:REACT_79539 \"Notch 4 precursor cleaved to form a heterodimer, Canis familiaris\"" . "Reactome:REACT_7959 \"Conversion of C2 into C2a and C2b, Homo sapiens\"" . "Reactome:REACT_79601 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Mus musculus\"" . "Reactome:REACT_79616 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Bos taurus\"" . "Reactome:REACT_79687 \"Processing of classical PDGFs, Bos taurus\"" . "Reactome:REACT_7977 \"Activation of C1S, Homo sapiens\"" . "Reactome:REACT_7978 \"Activation of C1R, Homo sapiens\"" . "Reactome:REACT_7981 \"Factor D cleaves C3(H2O)-bound Factor B, Homo sapiens\"" . "Reactome:REACT_79835 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Mus musculus\"" . "Reactome:REACT_7986 \"Formation of alternate C5 convertase, Homo sapiens\"" . "Reactome:REACT_7989 \"Activation of C5, Homo sapiens\"" . "Reactome:REACT_7990 \"Cleavage of C3 by C3 convertases, Homo sapiens\"" . "Reactome:REACT_79971 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Gallus gallus\"" . "Reactome:REACT_8002 \"Conversion of C4 into C4a and C4b, Homo sapiens\"" . "Reactome:REACT_80078 \"Conversion of C4 into C4a and C4b, Mus musculus\"" . "Reactome:REACT_80147 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Danio rerio\"" . "Reactome:REACT_8026 \"Factor D cleaves C3b-bound Factor B, Homo sapiens\"" . "Reactome:REACT_80346 \"Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Mus musculus\"" . "Reactome:REACT_80454 \"Processing of preproGLP-1 to proGLP-1, Danio rerio\"" . "Reactome:REACT_80614 \"Processing of classical PDGFs, Danio rerio\"" . "Reactome:REACT_80657 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Bos taurus\"" . "Reactome:REACT_80718 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Taeniopygia guttata\"" . "Reactome:REACT_80779 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Bos taurus\"" . "Reactome:REACT_80788 \"Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Rattus norvegicus\"" . "Reactome:REACT_80828 \"Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Canis familiaris\"" . "Reactome:REACT_80892 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Mus musculus\"" . "Reactome:REACT_80961 \"Cleavage of C3 by C3 convertases, Mus musculus\"" . "Reactome:REACT_81323 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Rattus norvegicus\"" . "Reactome:REACT_81333 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Bos taurus\"" . "Reactome:REACT_81337 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Taeniopygia guttata\"" . "Reactome:REACT_81354 \"Notch 2 precursor cleaved to form a heterodimer, Rattus norvegicus\"" . "Reactome:REACT_81372 \"Part of pro-beta-NGF is processed to mature beta-NGF, Danio rerio\"" . "Reactome:REACT_81541 \"Cleavage of ATF6-alpha by S1P, Sus scrofa\"" . "Reactome:REACT_81561 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Gallus gallus\"" . "Reactome:REACT_81777 \"Activation of C1R, Rattus norvegicus\"" . "Reactome:REACT_81795 \"pro-protein C -> protein C + protein C propeptide, Mus musculus\"" . "Reactome:REACT_81849 \"Conversion of C4 into C4a and C4b, Xenopus tropicalis\"" . "Reactome:REACT_82153 \"Thrombin-mediated activation of Proteinase-activated receptors, Sus scrofa\"" . "Reactome:REACT_82158 \"Notch 1 precursor cleaved to form a heterodimer, Taeniopygia guttata\"" . "Reactome:REACT_82372 \"pro-protein C -> protein C + protein C propeptide, Bos taurus\"" . "Reactome:REACT_82390 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Mus musculus\"" . "Reactome:REACT_82497 \"Notch 3 precursor cleaved to form a heterodimer, Rattus norvegicus\"" . "Reactome:REACT_82637 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Gallus gallus\"" . "Reactome:REACT_82647 \"pro-protein Z -> protein Z + protein Z propeptide, Bos taurus\"" . "Reactome:REACT_82729 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Xenopus tropicalis\"" . "Reactome:REACT_82816 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Danio rerio\"" . "Reactome:REACT_82968 \"Cleavage of C3 by C3 convertases, Bos taurus\"" . "Reactome:REACT_83445 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Canis familiaris\"" . "Reactome:REACT_83461 \"pro-factor X -> factor X + factor X propeptide, Canis familiaris\"" . "Reactome:REACT_83499 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Danio rerio\"" . "Reactome:REACT_83770 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Bos taurus\"" . "Reactome:REACT_83777 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Danio rerio\"" . "Reactome:REACT_84044 \"Cleavage of C3 by C3 convertases, Danio rerio\"" . "Reactome:REACT_84046 \"Activation of C5, Bos taurus\"" . "Reactome:REACT_84129 \"Processing of classical PDGFs, Rattus norvegicus\"" . "Reactome:REACT_84217 \"Processing of classical PDGFs, Canis familiaris\"" . "Reactome:REACT_84258 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Mus musculus\"" . "Reactome:REACT_84261 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Xenopus tropicalis\"" . "Reactome:REACT_84305 \"pro-factor X -> factor X + factor X propeptide, Sus scrofa\"" . "Reactome:REACT_84322 \"pro-protein S -> protein S + protein S propeptide, Canis familiaris\"" . "Reactome:REACT_84434 \"Activation of C5, Mus musculus\"" . "Reactome:REACT_84524 \"Factor D cleaves C3b-bound Factor B, Sus scrofa\"" . "Reactome:REACT_84531 \"factor Va -> factor Vi, Canis familiaris\"" . "Reactome:REACT_84561 \"Formation of alternate C5 convertase, Bos taurus\"" . "Reactome:REACT_84599 \"Processing of preproGIP to proGIP, Mus musculus\"" . "Reactome:REACT_84623 \"Activation of C1R, Mus musculus\"" . "Reactome:REACT_84646 \"factor V -> factor Va + factor V activation peptide, Xenopus tropicalis\"" . "Reactome:REACT_84664 \"Latent TGF-beta1 is cleaved by furin, Mus musculus\"" . "Reactome:REACT_84693 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Mus musculus\"" . "Reactome:REACT_84795 \"Conversion of C4 into C4a and C4b, Sus scrofa\"" . "Reactome:REACT_84822 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Sus scrofa\"" . "Reactome:REACT_85002 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Mus musculus\"" . "Reactome:REACT_85145 \"factor VII -> factor VIIa, Xenopus tropicalis\"" . "Reactome:REACT_85207 \"pro-protein S -> protein S + protein S propeptide, Taeniopygia guttata\"" . "Reactome:REACT_85433 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Gallus gallus\"" . "Reactome:REACT_85635 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Gallus gallus\"" . "Reactome:REACT_85732 \"pro-protein S -> protein S + protein S propeptide, Bos taurus\"" . "Reactome:REACT_85824 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Sus scrofa\"" . "Reactome:REACT_85897 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Gallus gallus\"" . "Reactome:REACT_85916 \"pro-protein C -> protein C + protein C propeptide, Danio rerio\"" . "Reactome:REACT_86048 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Danio rerio\"" . "Reactome:REACT_86053 \"pro-factor VII -> factor VII + factor VII propeptide, Mus musculus\"" . "Reactome:REACT_86117 \"Granzyme-B activates BID by cleavage, Rattus norvegicus\"" . "Reactome:REACT_86243 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Mus musculus\"" . "Reactome:REACT_86385 \"Notch 1 precursor cleaved to form a heterodimer, Xenopus tropicalis\"" . "Reactome:REACT_86440 \"Notch 2 precursor cleaved to form a heterodimer, Sus scrofa\"" . "Reactome:REACT_86442 \"Notch 3 precursor cleaved to form a heterodimer, Xenopus tropicalis\"" . "Reactome:REACT_86459 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Xenopus tropicalis\"" . "Reactome:REACT_86497 \"Activation of C1S, Bos taurus\"" . "Reactome:REACT_86530 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus\"" . "Reactome:REACT_86627 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Bos taurus\"" . "Reactome:REACT_86670 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Bos taurus\"" . "Reactome:REACT_86747 \"pro-factor IX -> factor IX + factor IX propeptide, Bos taurus\"" . "Reactome:REACT_86842 \"Notch 3 precursor cleaved to form a heterodimer, Danio rerio\"" . "Reactome:REACT_86885 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Bos taurus\"" . "Reactome:REACT_86898 \"factor VII -> factor VIIa, Bos taurus\"" . "Reactome:REACT_86969 \"factor XII -> factor XIIa, Mus musculus\"" . "Reactome:REACT_87075 \"pro-factor VII -> factor VII + factor VII propeptide, Rattus norvegicus\"" . "Reactome:REACT_87266 \"Processing of Proglucagon to Glucagon-like Peptide-1, Danio rerio\"" . "Reactome:REACT_87452 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Canis familiaris\"" . "Reactome:REACT_87454 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Danio rerio\"" . "Reactome:REACT_87599 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Xenopus tropicalis\"" . "Reactome:REACT_87700 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Rattus norvegicus\"" . "Reactome:REACT_87792 \"Activation of C5, Sus scrofa\"" . "Reactome:REACT_87800 \"Notch 2 precursor cleaved to form a heterodimer, Xenopus tropicalis\"" . "Reactome:REACT_87920 \"Cleavage of ATF6-alpha by S1P, Rattus norvegicus\"" . "Reactome:REACT_88355 \"Activation of C5, Danio rerio\"" . "Reactome:REACT_88360 \"Extracellular processing of novel PDGFs, Danio rerio\"" . "Reactome:REACT_88496 \"Notch 2 precursor cleaved to form a heterodimer, Mus musculus\"" . "Reactome:REACT_88788 \"Notch 2 precursor cleaved to form a heterodimer, Danio rerio\"" . "Reactome:REACT_88823 \"Part of pro-beta-NGF is processed to mature beta-NGF, Gallus gallus\"" . "Reactome:REACT_88980 \"Conversion of C4 into C4a and C4b, Canis familiaris\"" . "Reactome:REACT_89126 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Taeniopygia guttata\"" . "Reactome:REACT_89188 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Rattus norvegicus\"" . "Reactome:REACT_89330 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Gallus gallus\"" . "Reactome:REACT_89358 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Bos taurus\"" . "Reactome:REACT_89476 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Bos taurus\"" . "Reactome:REACT_89486 \"Cleavage of the Signal Peptide of Preproghrelin, Sus scrofa\"" . "Reactome:REACT_89678 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Danio rerio\"" . "Reactome:REACT_89776 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Canis familiaris\"" . "Reactome:REACT_89824 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Rattus norvegicus\"" . "Reactome:REACT_89888 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Canis familiaris\"" . "Reactome:REACT_89976 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Mus musculus\"" . "Reactome:REACT_9 \"factor VII -> factor VIIa, Homo sapiens\"" . "Reactome:REACT_90020 \"Notch 1 precursor cleaved to form a heterodimer, Gallus gallus\"" . "Reactome:REACT_90057 \"Activation of C5, Canis familiaris\"" . "Reactome:REACT_90119 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Gallus gallus\"" . "Reactome:REACT_90443 \"Thrombin-mediated activation of Proteinase-activated receptors, Gallus gallus\"" . "Reactome:REACT_905 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Homo sapiens\"" . "Reactome:REACT_90541 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Canis familiaris\"" . "Reactome:REACT_90557 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Rattus norvegicus\"" . "Reactome:REACT_90602 \"Notch 1 precursor cleaved to form a heterodimer, Bos taurus\"" . "Reactome:REACT_90751 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Mus musculus\"" . "Reactome:REACT_90855 \"Latent TGF-beta1 is cleaved by furin, Sus scrofa\"" . "Reactome:REACT_90888 \"Processing of Proglucagon to Glucagon-like Peptide-1, Bos taurus\"" . "Reactome:REACT_90902 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Bos taurus\"" . "Reactome:REACT_90939 \"pro-factor X -> factor X + factor X propeptide, Danio rerio\"" . "Reactome:REACT_91056 \"Factor D cleaves C3(H2O)-bound Factor B, Mus musculus\"" . "Reactome:REACT_91167 \"Part of pro-beta-NGF is processed to mature beta-NGF, Xenopus tropicalis\"" . "Reactome:REACT_91387 \"Extracellular processing of novel PDGFs, Xenopus tropicalis\"" . "Reactome:REACT_91461 \"Factor D cleaves C3(H2O)-bound Factor B, Danio rerio\"" . "Reactome:REACT_91543 \"Cleavage of the Signal Peptide of Preproghrelin, Canis familiaris\"" . "Reactome:REACT_91726 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Rattus norvegicus\"" . "Reactome:REACT_91877 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Rattus norvegicus\"" . "Reactome:REACT_92031 \"factor V -> factor Va + factor V activation peptide, Danio rerio\"" . "Reactome:REACT_92103 \"Latent TGF-beta1 is cleaved by furin, Rattus norvegicus\"" . "Reactome:REACT_92110 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Sus scrofa\"" . "Reactome:REACT_92215 \"Cleavage of the Signal Peptide of Preproghrelin, Gallus gallus\"" . "Reactome:REACT_92228 \"pro-protein S -> protein S + protein S propeptide, Gallus gallus\"" . "Reactome:REACT_92253 \"factor V -> factor Va + factor V activation peptide, Rattus norvegicus\"" . "Reactome:REACT_92261 \"Notch 4 precursor cleaved to form a heterodimer, Sus scrofa\"" . "Reactome:REACT_92422 \"pro-protein S -> protein S + protein S propeptide, Xenopus tropicalis\"" . "Reactome:REACT_92693 \"Latent TGF-beta1 is cleaved by furin, Bos taurus\"" . "Reactome:REACT_92748 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Sus scrofa\"" . "Reactome:REACT_92823 \"Notch 1 precursor cleaved to form a heterodimer, Canis familiaris\"" . "Reactome:REACT_92949 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Rattus norvegicus\"" . "Reactome:REACT_93064 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Gallus gallus\"" . "Reactome:REACT_93142 \"pro-factor X -> factor X + factor X propeptide, Bos taurus\"" . "Reactome:REACT_93405 \"factor VII -> factor VIIa, Mus musculus\"" . "Reactome:REACT_93445 \"factor XII -> factor XIIa, Canis familiaris\"" . "Reactome:REACT_93463 \"Notch 1 precursor cleaved to form a heterodimer, Drosophila melanogaster\"" . "Reactome:REACT_93480 \"factor Va -> factor Vi, Danio rerio\"" . "Reactome:REACT_93511 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Rattus norvegicus\"" . "Reactome:REACT_93561 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Taeniopygia guttata\"" . "Reactome:REACT_93736 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Rattus norvegicus\"" . "Reactome:REACT_94000 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Rattus norvegicus\"" . "Reactome:REACT_94036 \"factor VII -> factor VIIa, Gallus gallus\"" . "Reactome:REACT_94312 \"pro-protein Z -> protein Z + protein Z propeptide, Gallus gallus\"" . "Reactome:REACT_94368 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Danio rerio\"" . "Reactome:REACT_94599 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Mus musculus\"" . "Reactome:REACT_94754 \"factor V -> factor Va + factor V activation peptide, Canis familiaris\"" . "Reactome:REACT_94901 \"Processing of preproGIP to proGIP, Canis familiaris\"" . "Reactome:REACT_94902 \"Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Rattus norvegicus\"" . "Reactome:REACT_94933 \"Part of pro-beta-NGF is processed to mature beta-NGF, Canis familiaris\"" . "Reactome:REACT_94955 \"Cleavage of ATF6-alpha by S1P, Xenopus tropicalis\"" . "Reactome:REACT_94965 \"Formation of alternate C5 convertase, Sus scrofa\"" . "Reactome:REACT_95107 \"Thrombin-mediated activation of Proteinase-activated receptors, Rattus norvegicus\"" . "Reactome:REACT_95139 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Canis familiaris\"" . "Reactome:REACT_95191 \"pro-protein Z -> protein Z + protein Z propeptide, Xenopus tropicalis\"" . "Reactome:REACT_95211 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Mus musculus\"" . "Reactome:REACT_95236 \"Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Taeniopygia guttata\"" . "Reactome:REACT_95276 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Taeniopygia guttata\"" . "Reactome:REACT_95431 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Bos taurus\"" . "Reactome:REACT_95949 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Rattus norvegicus\"" . "Reactome:REACT_95979 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Mus musculus\"" . "Reactome:REACT_96137 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Canis familiaris\"" . "Reactome:REACT_96193 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Bos taurus\"" . "Reactome:REACT_96270 \"pro-factor IX -> factor IX + factor IX propeptide, Xenopus tropicalis\"" . "Reactome:REACT_96343 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Rattus norvegicus\"" . "Reactome:REACT_96382 \"Factor D cleaves C3b-bound Factor B, Mus musculus\"" . "Reactome:REACT_96526 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Sus scrofa\"" . "Reactome:REACT_97100 \"pro-protein Z -> protein Z + protein Z propeptide, Danio rerio\"" . "Reactome:REACT_97110 \"factor Va -> factor Vi, Xenopus tropicalis\"" . "Reactome:REACT_97353 \"factor XII -> factor XIIa, Bos taurus\"" . "Reactome:REACT_97421 \"pro-protein C -> protein C + protein C propeptide, Canis familiaris\"" . "Reactome:REACT_97432 \"Part of pro-beta-NGF is processed to mature beta-NGF, Bos taurus\"" . "Reactome:REACT_97564 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Taeniopygia guttata\"" . "Reactome:REACT_97673 \"pro-factor VII -> factor VII + factor VII propeptide, Bos taurus\"" . "Reactome:REACT_97699 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Xenopus tropicalis\"" . "Reactome:REACT_97708 \"Cleavage of ATF6-alpha by S1P, Bos taurus\"" . "Reactome:REACT_97710 \"Cleavage of ATF6-alpha by S1P, Mus musculus\"" . "Reactome:REACT_97801 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Sus scrofa\"" . "Reactome:REACT_97855 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Canis familiaris\"" . "Reactome:REACT_98063 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Rattus norvegicus\"" . "Reactome:REACT_98097 \"Activation of C1S, Xenopus tropicalis\"" . "Reactome:REACT_98147 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Gallus gallus\"" . "Reactome:REACT_98165 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Xenopus tropicalis\"" . "Reactome:REACT_98203 \"pro-GAS6 -> GAS6 + GAS6 propeptide, Danio rerio\"" . "Reactome:REACT_98267 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Rattus norvegicus\"" . "Reactome:REACT_98357 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Danio rerio\"" . "Reactome:REACT_98392 \"Extracellular processing of novel PDGFs, Rattus norvegicus\"" . "Reactome:REACT_98494 \"Processing of preproGLP-1 to proGLP-1, Taeniopygia guttata\"" . "Reactome:REACT_98565 \"Processing of preproGIP to proGIP, Rattus norvegicus\"" . "Reactome:REACT_98659 \"Factor D cleaves C3(H2O)-bound Factor B, Sus scrofa\"" . "Reactome:REACT_98696 \"pro-prothrombin -> prothrombin + prothrombin propeptide, Bos taurus\"" . "Reactome:REACT_98749 \"Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Bos taurus\"" . "Reactome:REACT_98786 \"Notch 3 precursor cleaved to form a heterodimer, Bos taurus\"" . "Reactome:REACT_98917 \"Formation of alternate C5 convertase, Canis familiaris\"" . "Reactome:REACT_99191 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Mus musculus\"" . "Reactome:REACT_99384 \"Processing of classical PDGFs, Taeniopygia guttata\"" . "Reactome:REACT_99395 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Canis familiaris\"" . "Reactome:REACT_99405 \"Notch 4 precursor cleaved to form a heterodimer, Rattus norvegicus\"" . "Reactome:REACT_99429 \"Processing of Proglucagon to Glucagon-like Peptide-1, Xenopus tropicalis\"" . "Reactome:REACT_99443 \"Cleavage of the Signal Peptide of Preproghrelin, Rattus norvegicus\"" . "Reactome:REACT_99555 \"pro-protein Z -> protein Z + protein Z propeptide, Taeniopygia guttata\"" . "Reactome:REACT_99585 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Rattus norvegicus\"" . "Reactome:REACT_99900 \"protein C -> activated protein C + protein C heavy chain activation peptide, Mus musculus\"" . "Reactome:REACT_99921 \"Granzyme-B activates BID by cleavage, Bos taurus\"" . "Reactome:REACT_99987 \"Notch 2 precursor cleaved to form a heterodimer, Bos taurus\"" . . . "blood coagulation factor activity" .