. "\"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.\" [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]" . . "metalloendopeptidase activity" . "metalloendoprotease activity" . "metalloendoproteinase activity" . "EC:3.4.24" . "Reactome:REACT_100500 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Mus musculus\"" . "Reactome:REACT_102187 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Bos taurus\"" . "Reactome:REACT_102738 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Rattus norvegicus\"" . "Reactome:REACT_104692 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Gallus gallus\"" . "Reactome:REACT_104704 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Canis familiaris\"" . "Reactome:REACT_105137 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Taeniopygia guttata\"" . "Reactome:REACT_105311 \"Pro-EGF is cleaved to form mature EGF, Rattus norvegicus\"" . "Reactome:REACT_109473 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Rattus norvegicus\"" . "Reactome:REACT_11089 \"BoNT Light Chain Type E cleaves SNAP-25, Homo sapiens\"" . "Reactome:REACT_111084 \"ADAM17 cleavage of Ghr, Mus musculus\"" . "Reactome:REACT_111197 \"Metalloprotease cleavage of GHR, Homo sapiens\"" . "Reactome:REACT_11130 \"BoNT Light Chain Type C1 cleaves SNAP-25, Homo sapiens\"" . "Reactome:REACT_11146 \"BoNT Light Chain Type A cleaves SNAP-25, Homo sapiens\"" . "Reactome:REACT_11158 \"BoNT Light Chain Type F cleaves VAMP, Homo sapiens\"" . "Reactome:REACT_11165 \"BoNT Light Chain Type B cleaves VAMP-2, Homo sapiens\"" . "Reactome:REACT_11179 \"BoNT Light Chain Type D cleaves VAMP, Homo sapiens\"" . "Reactome:REACT_11195 \"BoNT Light Chain Type C1 cleaves Syntaxin, Homo sapiens\"" . "Reactome:REACT_115618 \"Cleavage of P-ERBB4jmA isoforms by ADAM17, Homo sapiens\"" . "Reactome:REACT_115992 \"Cleavage of P-ERBB4jmA isoforms by Adam17, Homo sapiens\"" . "Reactome:REACT_13407 \"Conversion of pro-apoA-I to apoA-I, Homo sapiens\"" . "Reactome:REACT_15304 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Homo sapiens\"" . "Reactome:REACT_15447 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Homo sapiens\"" . "Reactome:REACT_15475 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Homo sapiens\"" . "Reactome:REACT_28155 \"Pro-EGF is cleaved to form mature EGF, Taeniopygia guttata\"" . "Reactome:REACT_28465 \"Pro-EGF is cleaved to form mature EGF, Xenopus tropicalis\"" . "Reactome:REACT_30819 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Taeniopygia guttata\"" . "Reactome:REACT_30876 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Bos taurus\"" . "Reactome:REACT_31204 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Mus musculus\"" . "Reactome:REACT_31767 \"Conversion of pro-apoA-I to apoA-I, Danio rerio\"" . "Reactome:REACT_32065 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Bos taurus\"" . "Reactome:REACT_33032 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Canis familiaris\"" . "Reactome:REACT_33649 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Gallus gallus\"" . "Reactome:REACT_34637 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Danio rerio\"" . "Reactome:REACT_46117 \"Pro-EGF is cleaved to form mature EGF, Gallus gallus\"" . "Reactome:REACT_48941 \"Conversion of pro-apoA-I to apoA-I, Bos taurus\"" . "Reactome:REACT_79685 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Canis familiaris\"" . "Reactome:REACT_81221 \"Pro-EGF is cleaved to form mature EGF, Canis familiaris\"" . "Reactome:REACT_83047 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Xenopus tropicalis\"" . "Reactome:REACT_84535 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Danio rerio\"" . "Reactome:REACT_85568 \"Pro-EGF is cleaved to form mature EGF, Danio rerio\"" . "Reactome:REACT_85944 \"Conversion of pro-apoA-I to apoA-I, Xenopus tropicalis\"" . "Reactome:REACT_87955 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Sus scrofa\"" . "Reactome:REACT_89938 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Xenopus tropicalis\"" . "Reactome:REACT_9030 \"Mouse pro-EGF is cleaved by ADAM sheddases, Mus musculus\"" . "Reactome:REACT_90847 \"Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Sus scrofa\"" . "Reactome:REACT_91391 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Mus musculus\"" . "Reactome:REACT_93439 \"Conversion of pro-apoA-I to apoA-I, Mus musculus\"" . "Reactome:REACT_9423 \"Pro-EGF is cleaved to form mature EGF, Homo sapiens\"" . "Reactome:REACT_96741 \"Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Taeniopygia guttata\"" . "Reactome:REACT_97379 \"Conversion of pro-apoA-I to apoA-I, Sus scrofa\"" . "Reactome:REACT_97836 \"Conversion of pro-apoA-I to apoA-I, Canis familiaris\"" . "Reactome:REACT_98257 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Rattus norvegicus\"" . "Reactome:REACT_98581 \"Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Sus scrofa\"" . . .