. "\"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.\" [ISBN:0198506732]" . . "aspartic-type endopeptidase activity" . "aspartate protease activity" . "aspartic endopeptidase activity" . "aspartic protease activity" . "aspartyl protease activity" . "carboxyl protease activity" . "EC:3.4.23" . "Reactome:REACT_100150 \"NEXT1 is cleaved to produce NICD1, Gallus gallus\"" . "Reactome:REACT_100746 \"NEXT2 is cleaved to produce NICD2, Rattus norvegicus\"" . "Reactome:REACT_102828 \"NEXT1 is cleaved to produce NICD1, Xenopus tropicalis\"" . "Reactome:REACT_103663 \"NEXT4 is cleaved to produce NICD4, Bos taurus\"" . "Reactome:REACT_103855 \"NEXT2 is cleaved to produce NICD2, Drosophila melanogaster\"" . "Reactome:REACT_106913 \"NEXT4 is cleaved to produce NICD4, Mus musculus\"" . "Reactome:REACT_108687 \"NEXT3 is cleaved to produce NICD3, Danio rerio\"" . "Reactome:REACT_108752 \"NEXT4 is cleaved to produce NICD4, Canis familiaris\"" . "Reactome:REACT_110055 \"NEXT2 is cleaved to produce NICD2, Xenopus tropicalis\"" . "Reactome:REACT_114839 \"NEXT4 is cleaved to produce NICD4, Xenopus tropicalis\"" . "Reactome:REACT_114927 \"NEXT3 is cleaved to produce NICD3, Drosophila melanogaster\"" . "Reactome:REACT_1306 \"NEXT2 is cleaved to produce NICD2, Homo sapiens\"" . "Reactome:REACT_1784 \"NEXT1 is cleaved to produce NICD1, Homo sapiens\"" . "Reactome:REACT_1803 \"NEXT3 is cleaved to produce NICD3, Homo sapiens\"" . "Reactome:REACT_28604 \"NEXT1 is cleaved to produce NICD1, Danio rerio\"" . "Reactome:REACT_29012 \"NEXT4 is cleaved to produce NICD4, Sus scrofa\"" . "Reactome:REACT_29591 \"NEXT4 is cleaved to produce NICD4, Rattus norvegicus\"" . "Reactome:REACT_30254 \"NEXT3 is cleaved to produce NICD3, Bos taurus\"" . "Reactome:REACT_32331 \"NEXT3 is cleaved to produce NICD3, Xenopus tropicalis\"" . "Reactome:REACT_34376 \"NEXT1 is cleaved to produce NICD1, Drosophila melanogaster\"" . "Reactome:REACT_77061 \"NEXT1 is cleaved to produce NICD1, Rattus norvegicus\"" . "Reactome:REACT_78562 \"NEXT2 is cleaved to produce NICD2, Canis familiaris\"" . "Reactome:REACT_78689 \"NEXT3 is cleaved to produce NICD3, Mus musculus\"" . "Reactome:REACT_80559 \"NEXT2 is cleaved to produce NICD2, Mus musculus\"" . "Reactome:REACT_82242 \"NEXT2 is cleaved to produce NICD2, Bos taurus\"" . "Reactome:REACT_82441 \"NEXT1 is cleaved to produce NICD1, Taeniopygia guttata\"" . "Reactome:REACT_89773 \"NEXT1 is cleaved to produce NICD1, Bos taurus\"" . "Reactome:REACT_89990 \"NEXT3 is cleaved to produce NICD3, Canis familiaris\"" . "Reactome:REACT_93093 \"NEXT2 is cleaved to produce NICD2, Gallus gallus\"" . "Reactome:REACT_93980 \"NEXT2 is cleaved to produce NICD2, Sus scrofa\"" . "Reactome:REACT_95514 \"NEXT1 is cleaved to produce NICD1, Canis familiaris\"" . "Reactome:REACT_96133 \"NEXT2 is cleaved to produce NICD2, Danio rerio\"" . "Reactome:REACT_96159 \"NEXT1 is cleaved to produce NICD1, Mus musculus\"" . "Reactome:REACT_965 \"NEXT4 is cleaved to produce NICD4, Homo sapiens\"" . "Reactome:REACT_97765 \"NEXT3 is cleaved to produce NICD3, Rattus norvegicus\"" . . .