. "\"Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.\" [GOC:txnOH, PMID:10213677, PMID:16858867]" . . "transcription cofactor activity" . "transcriptional co-regulator" . "transcriptional cofactor activity" . .