. . . . . . . . . . "HIV-1 Nef binds and activates Nef-associated kinase via interactions with the small GTPases CDC42 and Rac1, which are required for optimal levels of Nef-dependent viral replication in vivo" . "HIV-1 Nef-mediated activation of Vav induces an increase of active Rac1 levels" . "HIV-1 Nef interacts with Rac1 in a protein complex including DOCK2 and ELMO1" . "Rac1 inhibits HIV-1 Nef-mediated CD80 and CD86 relocation from cell surface to the intracellular compartment" . "interacts with" . "inhibited by" . "activates" . "Interacts with" .