. . . . . . . . . . . . . . . . . . "Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor" . "HIV-1 Tat activates mitogen-activated protein kinases ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as the activation of CREB and increased albumin permeability" . "MAP2K2 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells" . "downregulates" . "modulates" . "activates" .